Microglia as therapeutic target in central nervous system disorders

Microglia Initiate Central Nervous System

P171: Microglia Cell, Major Player in the Central Nervous System Inflammation

Inflammation, a self-defensive reaction against various pathogenic stimuli, may become harmful self-damaging process. Increasing evidence has linked chronic inflammation to a number of neurodegenerative disorders including alzheimer's disease (AD), parkinson's disease (PD), and multiple sclerosis (MS). In the central nervous system, microglia, the resident innate immune cells play major role in...

Microglia: gatekeepers of central nervous system immunology.

Microglia are perhaps the most underestimated cell type of our immune system. Not only were immunologists unaware of their capabilities until recently, but also, some neuroscientists denied their actual existence until the late 20th century. Nowadays, their presence is confirmed extensively, as demonstrated by numerous reports describing their involvement in virtually all neuropathologies. Howe...

Microglia--a therapeutic target in neurological diseases and disorders.

Microglia, the resident cells of the central nervous system (CNS) respond swiftly to a variety of acute and chronic stimuli. In response to various stimuli, both exogenous and endogenous, activated microglia showed increase production of trophic factors (e.g. insulin-like growth factors) and proinflammatory cytokines (e.g. TNF-α and IL-1β) or mediators (e.g. nitric oxide, reactive oxygen specie...

Ion Channels as Drug Targets in Central Nervous System Disorders

Ion channel targeted drugs have always been related with either the central nervous system (CNS), the peripheral nervous system, or the cardiovascular system. Within the CNS, basic indications of drugs are: sleep disorders, anxiety, epilepsy, pain, etc. However, traditional channel blockers have multiple adverse events, mainly due to low specificity of mechanism of action. Lately, novel ion cha...